This study demonstrates that filopodia speed up collective endothelial decisions during angiogenesis by conferring a bistable switch-like property to Notch lateral inhibition, ensuring rapid and robust tip cell selection.
Feb 2, 2021
Asymmetric division in endothelial tip cells generates daughters of distinct sizes and Vegfr signalling levels, driving coordinated collective cell migration in angiogenesis. This Dll4/Notch-independent mechanism integrates cell proliferation with migration, potentially aiding tissue growth during development, regeneration, and cancer invasion.
Dec 1, 2016
This study explores the role of active perception in generating bistability during angiogenesis. By examining endothelial cells (ECs) in a simulated environment, the study demonstrates that sensorimotor feedback can lead to bistability and influence collective decision timing.
Jul 30, 2014