Active perception during angiogenesis: filopodia speed up Notch selection of tip cells in silico and in vivo
This study demonstrates that filopodia speed up collective endothelial decisions during angiogenesis by conferring a bistable switch-like property to Notch lateral inhibition, ensuring rapid and robust tip cell selection.
Feb 2, 2021
Tales from the Trenches: Developing sciview, a new 3D viewer for the ImageJ community
This paper describes the development of sciview, a modern 3D viewer for the ImageJ community, highlighting sustainable development, community building, and software engineering best practices.
Apr 28, 2020
Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy
This study uses light-sheet fluorescence microscopy (LSFM) to demonstrate improved imaging techniques for mouse models of eye diseases, revealing new pathological features and offering advancements in understanding neurovascular and degenerative processes.
Feb 19, 2020
A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage
Actively cycling epithelial progenitors in the mouse incisor generate enamel-producing ameloblasts and non-ameloblast cells, coordinating tissue renewal and repair through progenitor-cell proliferation and Notch1-mediated cell conversion.
Sep 1, 2019
Multi-sample SPIM image acquisition, processing and analysis of vascular growth in zebrafish
We present a workflow for multi-sample SPIM imaging, processing, and analysis to study vascular growth in zebrafish, allowing simultaneous imaging and automated data processing, yielding precise quantification of vascular development.
Mar 20, 2019
FunImageJ: a Lisp framework for scientific image processing
FunImageJ is a Lisp framework for scientific image processing built upon the ImageJ software ecosystem, offering a functional programming style and performance suitable for big data biological image analysis.
Feb 26, 2018
Escalation of Memory Length in Finite Populations
This study explores the escalation of memory length in finite populations through coevolutionary simulations, demonstrating that larger population sizes support greater complexity and that escalation is sensitive to perturbations.
Apr 25, 2017
Asymmetric division coordinates collective cell migration in angiogenesis
Asymmetric division in endothelial tip cells generates daughters of distinct sizes and Vegfr signalling levels, driving coordinated collective cell migration in angiogenesis. This Dll4/Notch-independent mechanism integrates cell proliferation with migration, potentially aiding tissue growth during development, regeneration, and cancer invasion.
Dec 1, 2016
A circuit basis for morphogenesis
This paper explores the consequences of a circuit basis for reaction–diffusion systems on morphogenesis, including the reachability of patterns and the logical basis of pattern stability.
May 23, 2016
Configurable NOR gate arrays from Belousov-Zhabotinsky micro-droplets
We investigate the BZ reaction to establish a basis for computation using chemical oscillators coupled via inhibition, producing reliable NOR gates in a microfluidic experiment.
May 8, 2016